PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells
Identifieur interne : 000556 ( Main/Exploration ); précédent : 000555; suivant : 000557PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells
Auteurs : Chunle Zhao ; Ruizhi He ; Ming Shen ; Feng Zhu ; Min Wang ; Yuhui Liu ; Hua Chen ; Xu Li ; Renyi QinSource :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Pancreatic cancer (PC) is one of the most lethal diseases, and effective treatment of PC patients remains an enormous challenge. Rocaglamide A (Roc-A), a bioactive molecule extracted from the plant
Url:
DOI: 10.3389/fphar.2019.00968
PubMed: 31551778
PubMed Central: 6735223
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells</title><author><name sortKey="Zhao, Chunle" sort="Zhao, Chunle" uniqKey="Zhao C" first="Chunle" last="Zhao">Chunle Zhao</name></author><author><name sortKey="He, Ruizhi" sort="He, Ruizhi" uniqKey="He R" first="Ruizhi" last="He">Ruizhi He</name></author><author><name sortKey="Shen, Ming" sort="Shen, Ming" uniqKey="Shen M" first="Ming" last="Shen">Ming Shen</name></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Liu, Yuhui" sort="Liu, Yuhui" uniqKey="Liu Y" first="Yuhui" last="Liu">Yuhui Liu</name></author><author><name sortKey="Chen, Hua" sort="Chen, Hua" uniqKey="Chen H" first="Hua" last="Chen">Hua Chen</name></author><author><name sortKey="Li, Xu" sort="Li, Xu" uniqKey="Li X" first="Xu" last="Li">Xu Li</name></author><author><name sortKey="Qin, Renyi" sort="Qin, Renyi" uniqKey="Qin R" first="Renyi" last="Qin">Renyi Qin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31551778</idno><idno type="pmc">6735223</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735223</idno><idno type="RBID">PMC:6735223</idno><idno type="doi">10.3389/fphar.2019.00968</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000572</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000572</idno><idno type="wicri:Area/Pmc/Curation">000572</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000572</idno><idno type="wicri:Area/Pmc/Checkpoint">000508</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000508</idno><idno type="wicri:Area/Ncbi/Merge">000A48</idno><idno type="wicri:Area/Ncbi/Curation">000A48</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A48</idno><idno type="wicri:Area/Main/Merge">000556</idno><idno type="wicri:Area/Main/Curation">000556</idno><idno type="wicri:Area/Main/Exploration">000556</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells</title><author><name sortKey="Zhao, Chunle" sort="Zhao, Chunle" uniqKey="Zhao C" first="Chunle" last="Zhao">Chunle Zhao</name></author><author><name sortKey="He, Ruizhi" sort="He, Ruizhi" uniqKey="He R" first="Ruizhi" last="He">Ruizhi He</name></author><author><name sortKey="Shen, Ming" sort="Shen, Ming" uniqKey="Shen M" first="Ming" last="Shen">Ming Shen</name></author><author><name sortKey="Zhu, Feng" sort="Zhu, Feng" uniqKey="Zhu F" first="Feng" last="Zhu">Feng Zhu</name></author><author><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></author><author><name sortKey="Liu, Yuhui" sort="Liu, Yuhui" uniqKey="Liu Y" first="Yuhui" last="Liu">Yuhui Liu</name></author><author><name sortKey="Chen, Hua" sort="Chen, Hua" uniqKey="Chen H" first="Hua" last="Chen">Hua Chen</name></author><author><name sortKey="Li, Xu" sort="Li, Xu" uniqKey="Li X" first="Xu" last="Li">Xu Li</name></author><author><name sortKey="Qin, Renyi" sort="Qin, Renyi" uniqKey="Qin R" first="Renyi" last="Qin">Renyi Qin</name></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Pancreatic cancer (PC) is one of the most lethal diseases, and effective treatment of PC patients remains an enormous challenge. Rocaglamide A (Roc-A), a bioactive molecule extracted from the plant <italic>Aglaia elliptifolia</italic>, has aroused considerable attention as a therapeutic choice for numerous cancer treatments. Nevertheless, the effects and underlying mechanism of Roc-A in PC are still poorly understood. Here, we found that Roc-A inhibited growth and stimulated apoptosis by induction of mitochondria dysfunction in PC. Moreover, Roc-A accelerated autophagosome synthesis and triggered mitophagy involving the PTEN-induced putative kinase 1 (PINK1)/Parkin signal pathway. We also demonstrated that inhibition of autophagy/mitophagy can sensitize PC cells to Roc-A. Finally, Roc-A treatment results in an obvious accumulation of reactive oxygen species (ROS), and pretreatment of cells with the reactive oxygen species scavenger <italic>N</italic>-acetylcysteine reversed the apoptosis and autophagy/mitophagy induced by Roc-A. Together, our results elucidate the potential mechanisms of action of Roc-A. 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